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Epigenetic, psychological, and EEG changes after a 1-week retreat based on mindfulness and compassion for stress reduction: Study protocol of a cross-over randomized controlled trial
dc.contributor.author | Díez, Gustavo | |
dc.contributor.author | Martín Subero, Ignacio | |
dc.contributor.author | Zangri, Rosaria M. | |
dc.contributor.author | Kulis, Marta | |
dc.contributor.author | Andreu, Catherine | |
dc.contributor.author | Blanco, Ivan | |
dc.contributor.author | Roca Morales, Pablo | |
dc.contributor.author | Cuesta, Pablo | |
dc.contributor.author | García, Carola | |
dc.contributor.author | Garzón, Jesús | |
dc.contributor.author | Herradón, Carlos | |
dc.contributor.author | Riutort, Miguel | |
dc.contributor.author | Baliyan, Shishir | |
dc.contributor.author | Venero, César | |
dc.contributor.author | Vázquez, Carmelo | |
dc.date.accessioned | 2023-07-06T11:32:55Z | |
dc.date.available | 2023-07-06T11:32:55Z | |
dc.date.issued | 2023-03-05 | |
dc.identifier.citation | Gustavo G. Diez, Ignacio Martin-Subero, Rosaria M. Zangri, Marta Kulis, Catherine Andreu, Ivan Blanco, Pablo Roca, Pablo Cuesta, Carola García, Jesús Garzón, Carlos Herradón, Miguel Riutort, Shishir Baliyan, César Venero, Carmelo Vázquez: Epigenetic, psychological, and EEG changes after a 1-week retreat based on mindfulness and compassion for stress reduction: Study protocol of a cross-over randomized controlled trial. medRxiv 2023.03.03.23286782; doi: https://doi.org/10.1101/2023.03.03.23286782 | es |
dc.identifier.uri | https://hdl.handle.net/20.500.12766/444 | |
dc.description.abstract | Introduction The main objective of the study will be to evaluate the effects of two widely used standardized mindfulness-based programs [Mindfulness-Based Stress Reduction (MBSR) and Compassion Cultivation Training (CCT)], on epigenetic, neurobiological, psychological, and physiological variables. Methods The programs will be offered in an intensive retreat format in a general population sample of healthy volunteer adults. During a 7-day retreat, participants will receive MBSR and CCT in a crossover design where participants complete both programs in random order. After finishing their first 3-day training with one of the two programs, participants will be assigned to the second 3-day training with the second program. The effects of the MBSR and CCT programs, and their combination, will be measured by epigenetic changes (i.e., DNA methylation biomarkers), neurobiological and psychophysiological measures (i.e., EEG resting state, EKG, respiration patterns, and diurnal cortisol slopes), self-report questionnaires belonging to different psychological domains (i.e., mindfulness, compassion, well-being, distress, and general functioning), and stress tasks (i.e., an Arithmetic Stress Test and the retrieval of negative autobiographical memories). These measures will be collected from both groups on the mornings of day 1 (pre-program), day 4 (after finishing the first program and before beginning the second program), and day 7 (post-second program). We will conduct a 3-month follow-up using only the set of self-report measures. Discussion This study aims to shed light on the neurobiological and psychological mechanisms linked to meditation and compassion in the general population. The protocol was registered at clinicaltrials.gov (Identifier: NCT05516355; August 23, 2022). | es |
dc.language.iso | eng | es |
dc.publisher | medRxiv | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Epigenetic, psychological, and EEG changes after a 1-week retreat based on mindfulness and compassion for stress reduction: Study protocol of a cross-over randomized controlled trial | es |
dc.type | preprint | es |
dc.description.department | Psicología y Ciencias de la Salud | es |
dc.identifier.doi | 10.1101/2023.03.03.23286782 | |
dc.rights.accessRights | open access | es |
dc.subject.area | Personalidad, Evaluación y Tratamientos Psicológicos | es |
dc.subject.keyword | Retreat | es |
dc.subject.keyword | Mindfulness | es |
dc.subject.keyword | Compassion | es |
dc.subject.keyword | Meditation | es |
dc.subject.keyword | EEG | es |
dc.subject.keyword | Epigenetics | es |
dc.subject.keyword | Stress | es |
dc.subject.keyword | Emotion regulation | es |
dc.subject.keyword | Autobiographical memory | es |