@article{20.500.12766/855,
year = {2026},
month = {3},
url = {https://hdl.handle.net/20.500.12766/855},
abstract = {Background:
The lack of a universally accepted definition, a gold-standard assessment tool, and sufficient evidence-based interventions has hindered the integration of frailty into routine clinical practice, particularly outside geriatric medicine. For clinicians, health professionals, policymakers, and aging researchers, a unified framework based on robust evidence has become essential.

Objectives:
To provide a consensus on relevant aspects of frailty, including definition, attributes, misunderstandings, pathophysiology, phenotypes, assessment, biomarkers, management, stigmas, and future challenges, useful for epidemiological, clinical, and research applications across Europe.

Design:
Consensus document.

Setting:
Twenty-five research centers on frailty and healthy aging.

Measurements:
Relevant aspects of frailty.

Results:
This document presents a consensus regarding what frailty is and what it is not, the relationship between frailty and aging, common misunderstandings associated with frailty, its pathophysiology, and the biomarkers involved. It also addresses how frailty should be assessed and by whom, how it should be managed, the existence of frailty subphenotypes or subtypes, the stigma associated with being considered frail, gender-related considerations, and the current challenges and future directions in the field. Frailty is defined as the expression of an age-associated clinical phenotypic syndrome driven by the biology of aging, life-course environmental exposures, and disease burden. Its physiological basis lies in a heterogeneous decline of functional reserve across organ systems, accompanied by impaired homeostasis and reduced capacity to respond to stressors, ultimately predisposing individuals to adverse health outcomes, mainly disability.

Conclusions:
This consensus document on frailty provides a comprehensive framework useful for epidemiological, clinical, and research applications across Europe.},
publisher = {Elsevier},
title = {Consensus document on frailty: conceptualization, detection, multidisciplinary management and future roadmap},
doi = {10.1016/j.jnha.2026.10079},
journal = {The Journal of nutrition, health and aging},
keywords = {Frailty},
keywords = {Position statement},
keywords = {CIBERFES},
keywords = {Older adults},
keywords = {Aging},
volume = {30},
author = {Álvarez Bustos, Alejandro and Andres-Lacueva, Cristina and Ara, Ignacio and Arévalo, María Ángeles and Bolaños, Juan P. and Coto-Montes, Ana and Enriquez, José Antonio and Escames, Germaine and García-García, Francisco José and Gómez-Cabrera, María Carmen and Grau-Rivera, Oriol and Izquierdo, Mikel and Martínez Velilla, Nicolás and Matheu, Ander and Menéndez Colino, Rocío and Muñoz Torres, Manuel and Nogués, Xavier and Oliva, Juan and Orts-Cortés, María Isabel and Párraga Martínez, Ignacio and Priego, Feliciano and Rabassa-Bonet, Montserrat and Rol, María Ángeles and Serra-Rexach, José Antonio and Tarazona-Santabalbina, Francisco José and Rodriguez-Mañas, Leocadio and Abizanda, Pedro},
}